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The disconnect between this promising science and clinical application is stark: not a single human trial exists for mental health applications, leaving patients and clinicians with compelling mechanisms but zero human efficacy or safety data

In many solid tumors, extracellular matrix deposition, cancer-associated fibroblast activation and elevated interstitial fluid pressure restrict the movement of nanoparticles from perivascular regions into deeper tumor tissue [14, 17, 30, 32, 34]

B12 inclusion theoretically mitigates this, but it cannot completely compensate for a 500-1000 calorie daily deficit

ERK, Extracellular Signal-Regulated Kinase